High-speed flow-cell image analysis system for real-time particle size and shape measurement in liquid dispersions at high throughput.
This dynamic image analysis system images particles flowing through a measurement cell at high speed, capturing thousands of individual particle images per second. Each image is analyzed to extract size and shape parameters simultaneously, providing true statistical particle characterization in flow — ideal for process monitoring and real-time QC.
This dynamic image analysis (DIA) system operates on the flow-cell principle: the sample dispersion is pumped continuously through a flat, optically transparent measurement cell at a controlled flow rate. A pulsed LED illuminates the flow cell with nanosecond flashes, effectively freezing particle motion for blur-free imaging even at high velocities. The high-speed camera captures sharp images of individual particles as they pass through the field of view.
Each captured particle image is automatically segmented and analyzed by the software to extract a comprehensive set of size and shape descriptors — including equivalent circle diameter, Feret diameters, perimeter, area, circularity, aspect ratio, elongation, convexity, and solidity. With camera speeds up to 1000 fps, over one million individual particles can be characterized in a typical measurement, providing superior statistical sampling compared to static image analysis methods.
The flow-cell architecture makes the instrument particularly suitable for process analytical technology (PAT) applications — where continuous, real-time particle monitoring during production processes provides immediate feedback for process control and optimization.
| Method | Dynamic Image Analysis in flow cell (ISO 13322-2) |
| Size Range | 0.5 µm – 5 mm |
| Camera Frame Rate | Up to 1000 fps |
| Particles Analyzed | > 1,000,000 per measurement |
| Shape Parameters | Circularity, elongation, aspect ratio, convexity |
| Flow Rate | 1 – 100 mL/min |
| Sample Volume | > 5 mL |
| Illumination | Pulsed LED (< 1 ns exposure) |
| Resolution | Sub-µm optical resolution |
| Software | Real-time display + batch analysis |
| Interface | USB, Ethernet |
| Wetted Materials | Borosilicate glass, PTFE, SS316 |
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